Evaluation of Pretreatment Method for Analysis of Perfluorinated Compounds in Human Blood and Breast Milk Samples

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Research article

Journal of the Korean Society for Environmental Analysis 2011;14(1):45-54.

혈액과 모유 시료 중 과불화화합물 분석을 위한 전처리법 평가

이응선¹, 김희영¹, 심원진², 이지현¹, 오정은¹, 김형식¹

¹부산대학교
²한국화학융합시험연구원

Abstract

In this study, we evaluated extraction methods for the analysis of perfluorinated compounds (PFCs) in human serum and breast milk samples. The recovery efficiencies of ion pairing extraction (IPE) and solid phase extraction (SPE) in each serum and breast milk were examined. For serum samples, IPE was more efficient (recovery efficiency: 81-105%) than SPE. For breast milk samples, except for perfluorododecanoic acid (PFDoA), SPE showed better recoveries (80-98%) than IPE. As results of validity test, accuracy and precision were in the range of 81~130% and 1~18% in serum, and 54~130% and 2~17% in breast milk, respectively. We also analyzed PFCs in the cord serum and breast milk from 13 pregnant women using the method established in this study. In the cord serum, all PFCs except for perfluorobutane sulfonate, perfluoroheptane sulfonate and perfluorohexanoic acid were detected. In the breast milk, perfluorooctane sulfonate, perfluorooctanoic acid and PFDoA were detected dominantly compared with other PFCs.

Key Words: breast milk, human blood, IPE, PFCs, SPE