J Korean Soc Environ Anal Search


Journal of the Korean Society for Environmental Analysis 2019;22(2):77-83.
Published online June 30, 2019.
ToxCastTM Program for High Throughput Screening of EnvironmentalChemical Toxicity, a Review
Jaeseong Jeong1, Changwon Lim2, Da Woon Jung3, Jinhee Choi1
1School of Environmental Engineering, University of Seoul, Seoul, 02504, Korea
2Department of Applied Statistics, Chung-Ang University, Seoul, 06974, Korea
3Department of Living Environment Research, Korea Environment Institute, Sejong, 30147, Korea
화학물질 독성고속대량스크리닝 프로그램 ToxCastTM 분석
정재성1, 임창원2, 정다운3, 최진희1
3한국환경정책·평가연구원 환경위해연구실
Correspondence:  Jinhee Choi, Tel: 82-2-6490-2869, Fax: 82-2-6490-2859, 
Email: jinhchoi@uos.ac.kr
Received: 17 April 2019   • Revised: 5 June 2019   • Accepted: 19 June 2019
As the number of new chemicals increases, traditional animal testinghas limitations in evaluating the toxicity of chemicals. In Europe and the United States, the use of non-animal alternative toxicity test methods for chemical regulation is encouraged and related research is actively carried out. In the United States, the ToxCast program is in progress using high-throughput screening (HTS) techniques. The program produced HTS in vitrotest results for 1200 assays and 9000 chemicals to develop chemical toxicity prediction models and set the priorities for toxicity assessment. In this review, we explored the outline of ToxCast, the types of assays used, and the progress of each phase. We also explored how to analyze the numerous toxicity data generated through the ToxCast program, including pre-processing, dose-response model fit, conclusion and categorization. Finally, implications for domestic utilization ofthe ToxCast database are derived.
Key Words: ToxCast, High Throughput Screening, Chemical toxicity, Data analysis, Regulatory science
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