| In Vitro Mammalian Chromosomal Aberration Assay with Methyl Tert-butyl Ether and Furfuryl Alcohol in Chinese Hamster Lung Cells |
|
|
| Abstract |
|
It was performed the in vitro mammalian chromosomal aberration (CA) assay to gain additional information concerning the hazards associated with the use of methyl tert-butyl ether (CAS No. 1634-04-4) and furfuryl alcohol (CAS No. 98-00-0). The assay was performed using the Chinese hamster lung fibroblast cell (CHL/IU cell), by the direct method (-S9) and by the metabolic activated method (+S9 mix).Using the direct method,the 7 dosages in a 48 hour treatment group did not show that the frequency of CA is proportion to the dosage addition. The frequency of CA is not proportion to the dosage addition for a 6 hour treatment using the metabolic activated method. From these findings, it was decided that the two chemicals do not induce chromosomal aberrations under the tested conditions. |
| Key Words:
methyl tert-butyl ether, furfuryl alcohol, chromosomal aberration, in vitro, Chinese hamster lung |
|
PDF Links
Full text via DOI
Download Citation
