| Electrochemical Behavior of Udenafil on Glass Carbon Electrode |
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| Abstract |
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The voltammetric behavior of udenafil on glassy carbon electrode was studied using cyclic, linear sweep and square-wave (SW) techniques. Udenafil showed an irreversible oxidation behavior in aqueous buffer solutions containing 30% (v/v) acetonitrile over the pH range of 2 to 6. The oxidation pattern of 2-(2-aminoethyl)-1-methylpyrrolidine differs from that of udenafil. On the other hand, the oxidation of udenafil resembles those of the alkoxybenzene group and 6-hydroxypurine group of udenafil and 5-(2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-7-pyramidinone (EMPP). From the linear relation between the peak current and the concentration of udenafil, square wave (SW) voltammetric method for its determination in udenafil tablets was developed. For analytical purpose, one well-defined diffusion controlled voltammetric peak was obtained in 0.2 M phosphate buffer at pH 2.0. The current-concentration plot was rectilinear over the range of 5×10^−7 to 5×10^−5 M with correlation coefficient of 0.998. |
| Key Words:
Udenafil, Oxidation mechanism, Drug analysis, Voltammetry |
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