| Analysis of Pharmaceutical Compounds in Water using Solid Phase Extraction (SPE) and Liquid Chromatography/Mass Spectrometry (LC/MS) |
| 고상추출법과 액체크로마토그래프 질량분석장치를 이용한 수질시료에서의 의약물질 분석 |
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이은영, 오정은, 심원진 |
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부산대학교 |
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| Abstract |
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SPE (solid-phase extraction) and LC/MS (liquid chromatography/mass spectrometry) method has been
developed for the analysis of thirty three pharmaceuticals in aqueous sample, such as sewage and river water.
The effects of disk type and pH on the extraction of pharmaceuticals in water were examined. Hydrophilic
DVB disk was more efficient than otadecyl (C18) disk and the extraction efficiency of pharmaceuticals at
pH=2 (53-139%) was better than that at pH=5. Thirty three pharmaceutics in sewage influent, effluent and river
sample were analyzed using the method developed in this study. Fourteen drugs (acetaminophen, acetylsalicylic
acid, diclofenac-Na, ibuprofen, ketoprofen, mefenamic acid, naproxen, carbamazepine, clofibric acid,
gemfibrozil, caffeine, erythromycin-H₂O, lincomycin, and amoxicillin) were detected and the levels of detection
were 0.001~10.1 ppb (μg/L). |
| Key Words:
pharmacueticals, sewage treatment plants (STPs), Liquid Chromatography/Mass Spectrometry
(LC/MS), Solid Phase Extraction (SPE) |
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